TESTING MODALITIES


Molecular testing looks for specific inherited changes (mutations) in a person’s genetic make-up. Genetic mutations may have multiple different effects on a patient’s health. Mutations that are harmful may increase a person’s chance, or risk, of developing a disease such as cancer. Inherited mutations are thought to play a role in 5-10% of all cancers. These particular conditions are considered hereditary and appropriate genetic testing may be used to determine an individual’s risk.

Some people inherit mutation(s) in the germline, allowing for the mutations to be passed on from their parents and to their children. There are two classes of cellular genes: oncogenes and tumor suppressor genes. Often, multiple genetic mutations in a single individual are responsible for the development of hereditary cancers.
Genetic counseling and testing may be recommended for people who have had certain cancers or certain patterns of cancer in their family.
If you have any of the following, you might consider genetic testing:

• Several first-degree relatives (mother, father, sisters, brothers, children) with cancer.
• Many relatives on one side of the family who have had the same type of cancer.
• A cluster of cancers in your family that are known to be linked to a single gene mutation (such as breast, ovarian, and pancreatic cancers in your family).
• A family member with more than 1 type of cancer.
• Family members who had cancer at a younger age than normal for that type of cancer.
• Close relatives with cancers that are linked to rare hereditary cancer syndromes.
• A family member with a rare cancer, such as breast cancer in a male or retinoblastoma.
• Ethnicity (for example, Jewish ancestry is linked to ovarian and breast cancers).
• A physical finding that’s linked to an inherited cancer (such as having many colon polyps).
• A known genetic mutation in one or more family members who have already had genetic testing.


At Sun Health Advocates we have multiple offerings that cover a diverse range of specialties. However, there is one offering that we are particularly passionate about and that is our Pharmacogenomic test.

Pharmacogenomics is the study of how genes affect a person’s response to drugs. With a simple non invasive cheek swab we are able to help medical professionals and their patients come up with a drug regimen that will specifically work for them based on their genetic makeup. A blueprint that will show how each individual patient will metabolize the drugs they are prescribed. Having this test performed will help a doctor prescribe the right drug, at the right dose, the very first time. It is our mission to drastically reduce the number of adverse drug reactions that happen every single day. Some people inherit mutation(s) in the germline, allowing for the mutations to be passed on from their parents and to their children. There are two classes of cellular genes: oncogenes and tumor suppressor genes. Often, multiple genetic mutations in a single individual are responsible for the development of hereditary cancers.
Patients have differences in DNA that impact drug metabolism which may increase their likelihood of an adverse drug reaction:

More than 85% of the population have detectable variations in their DNA that increase their risk for adverse drug reactions.

Adverse drug reactions are the 4th leading cause of death nationwide with more than 8.6 million cases reported annually.

The FDA highlights pharmacogenomics data for more than 130 prescription medications, indicating their strong support for testing
Sun Health Advocates Genetics advises pharmacogenomics testing for patients that meet one or more of the following conditions:

Patients that experience less than optimal results from prescribed medications.

Patients with a personal or family history of adverse drug reactions in response to certain medications.

Polypharmacy patients; those taking multiple prescription medications for multiple chronic conditions.

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